Posts Tagged ‘CDP-Choline’

7
Dec

Minimal Effective Stack, v2.0

by adminadam in articles

The Stack

  1. Creatine — 5g powder, AM
  2. Noopept — 10mg capsule, AM/noon/PM
  3. CDP-choline — 400mg capsule, AM/PM
  4. Modafinil — 100-200mg tablet, AM
  5. Ashwagandha — 570mg capsule, AM/PM
  6. Rhodiola — 500mg capsule, AM
  7. Probiotics — one capsule, AM
  8. Cod Liver Oil — three 650mg soft-gels, AM/PM
  9. Nicotine Gum — 1mg gum, PM
  10. Melatonin — 1mg tablet, Night

Changes Since Version 1

I have switched out piracetam for noopept. My main reasoning is to reduce the quantity of both powders and capsules that I consume. So I can cut my total piracetam powder levels from what they were previously — about six grams per day — to just three 10mg capsules per day of noopept.

I have added CPD-choline back in. While I have never experience an acetylcholine-depletion headache from taking racetams, I have heard that CDP-choline helps maintain cognitive abilities under sleep deprivation and also can help with dry eyes, both of which I experience at times.

I have removed Bacopa and added Ashwagandha. This was a hard choice which I took a long time to arrive at. Bacopa is lauded as the only effective, cheap, and safe way to truly improve your memory from a young-healthy subject baseline. But it made me excessively sleepy and caused me extreme stomach upset whenever I consumed it without food. These simple hindrances were what led me to cut it from my stack. While I enjoyed its anxiolytic (anxiety-reducing) effects, I had experienced stronger effects of that nature from Ashwagandha, an all-around resiliency-enhancing herbal supplement also from the Ayurvedic tradition. Ashwagandha improves immunity, reduces stress, and reduces insomnia in many subjects. I have experienced reduced stress and anxiety. Other effects are questionably related to many of the supplements I take, like Modafinil and Creatine for enhanced energy and motivation. Ashwagandha may also be contributing to these positive outcomes.

I have changed from Fish Oil to Cod Liver Oil. Cod Liver Oil is said to contain more Vitamin A and D. I take these soft-gels in ample quantities, sometimes up to nine a day, if I feel like I need the Vitamin D for enhanced immunity or serotonin production in the winter months.

I dropped Lion’s Mane Mushroom after listening to a podcast on the medicinal mushroom industry. It seems that the quality of many of these supplements is suspect, with the greater-guarantees-of-quality brands costing an arm and a leg. I’d prefer to save the money.

I have added Melatonin to the list. In fact, I have always used Melatonin to get to sleep faster, fight insomnia, and serve as an anti-oxidant. Now that I’m using lower doses of 1-2mg per night, I feel more refreshed waking up than I used to when I took between 3mg and 6mg. Research shows that 0.5mg to 1mg is the most effective dose. Melatonin is especially helpful if you are in front of bright screens with blue light in the evening, or if you drink lots of caffeinated beverages, or if you take modafinil mid-day or — heaven forbid — late in the day.

What I’ve Kept the Same

Creatine is a godsend for athletes. I am running regularly now, in addition to lifting weights, and I find I have the energy to give an extra push at the end of nearly all of my workouts because of Creatine. It is also said to boost cognition in individuals with low natural levels of Creatine in their diets.

Modafinil keeps me productive and emotionally-intelligent after late nights spent hanging out with my brother or my girlfriend, or after working to the wee hours of the morning on Linux projects. Speaking of which, check out my new blog: Kernelmastery.com. You might say Modafinil is the Mascot for Kernel Mastery.

Rhodiola I would never abandon. It enhances immunity, fights stress, and helps you fight fatigue. It is a tried-and-true resiliency supplement.

Probiotics for the gut; a healthy gut for a healthy mind.

Nicotine Gum eases my stress, wakes me up on my long drives home from work, and reboots the cognitive engines after a long work day. With Nicotine Gum, I can avoid drinking large quantities of caffeine in the afternoon. Most gums come in two- or four-milligram sizes. Because one milligram is plenty for me, I simply buy the two milligram version and cut the pieces in half. Easy and cheap!

16
May

My Current Stack, v3.0

by adminadam in home

Nootropic Stack — Version 3 — May 2015

BENEFITS ACTIVITIES AMOUNTS FREQUENCY NOTES
anxiolysis, focus Meditation 10-15 minutes weekday mornings breathing exercise: nose 5 sec. in, mouth 10 sec out. repeat x10.
memory, focus Study Japanese 15-20 minutes weekday mornings helps discipline in other areas
energy, focus, muscle tissue, immune support, balance, flexibility Taekwondo & Muy Thai one hour classes two times per week self-defense, sparring, board breaking, weapon training, and “forms”
anxiolysis, focus, muscle tissue, balance, flexibility Slacklining 5-30 minutes once a week on average, more in the summer excellent for core and leg strength and balance
BENEFITS SUBSTANCE AMOUNTS FREQUENCY NOTES
wakefulness, executive function Modafinil 200-300mg tablet weekday mornings upon waking drink lots of water. add salt to maintain electrolytes.
wakefulness, anxiolysis Matcha Green Tea [buy] 4-6 grams powder, mixed in water from waking through early afternoon works with cold water.  contains calming L-theanine.
anxiolysis, immune support, hormonal balance Ashwagandha [buy] 500mg capsule with 300mg KSM-66 standardized extract and 200mg whole root powder twice a day calming and pro-social
anxiolysis Tianeptine Sodium 12.5mg powder three times a day powerful depression and anxiety relief
anxiolysis, energy Bromantane 75-100mg powder weekday mornings upon waking powerful anxiety relief
anxiolysis, energy, immune support Rhodiola Rosea [buy] 500mg capsule, 3% standardized extract once a day upon waking best on empty stomach
energy, executive function, muscle tissue Creatine Monohydrate 5 grams powder once a day upon waking increased muscle definition. slight initial muscle bloating.
energy, muscle tissue L-citrulline, DL-malate (2:1 powder) 3 grams powder once a day upon waking and after taekwondo in the evening reduces muscle cramping and soreness
focus, verbal fluency Oxiracetam 800-1200mg powder four times a day subtly stimulating and anxiolytic
focus, memory CDP-choline 400mg capsule three times a day helps with verbal fluency
memory, anxiolysis Bacopa Monnieri [buy] 250mg capsule, standardized to 45% bacosides twice a day take with food. memorizing names and kanji quicker.
memory, anti-demetia and cognitive function, myelination Lion’s Mane Mushroom [buy] 500mg capsule twice a day just started taking in May. waiting to see effects.
 memory, reaction speed Vinpocetine [buy] 10mg tablet two or three times a day subtly stimulating. increases cerebral blood flow.
anti-inflammation Turmeric Root 1-2 tbsp powder once a day upon waking helps fight and prevent sinus infections
turmeric bioavailability Black Pepper 50-100mg once a day upon waking helps with turmeric absorption. reports of modafinil tolerance reduction.
serotonin production, immune support Vitamin D two liquid drops = 4000 IU once a day upon waking take extra when a cold is coming on
fluoride detox, metabolism Iodine [buy] three liquid drops = 7-8mg once a day upon waking fluoride detox symptoms, albeit temporary, suck: acne, fever, nausea
gut health Raw Unmodified Potato Starch [buy] 1 tbsp twice a day mixes with water. causes flatulence initially.
electrolyte balance Pink Sea Salt 1/2 tsp two or three times a day increases thirst and water retention
electrolyte balance, muscle tissue Potassium (Citrate/Aspartate) 99mg capsule once a day as needed helps prevent muscle cramping after workouts
sleep quality Magnesium Glycinate 2 grams powder once a day before bed calming. increases amount of dreams at night.
muscle tissue, immune support L-glutamine 2-4 grams powder once a day upon waking and after taekwondo in the evenings reduces muscle cramping. reports of anxiety reduction.
gut health Primal Defense Ultra Probiotic [buy] 750mg capsule once or twice a day healthy gut, healthy mind!
vitamin A/D, omega 3’s Cod Liver Oil [buy] two 650mg softgels = 5000 IU vitamin A, 600 IU vitamin D, 30mg EPA, 30mg DHA once a day upon waking take extra when a cold is coming on
sleep quality Melatonin [buy] 3mg 20-30 minutes before bed increases number of dreams at night
joint health Glucosamine and MSM [buy] two 1500mg tablets = 1500mg glucosamine hydrochloride, 1500mg MSM once a day upon waking helps my wife fight arthritis
immune support, anti-inflammation Oregano Essential Oil [buy] one to two drops, 83% carvacrol one to three times a day helps fight colds, infection, parasites, viruses
immune support, heavy metal detox Chlorella Powder two to three grams once or twice a day reports of reduction in allergy symptoms
BENEFITS SUBSTANCE AMOUNTS FREQUENCY NOTES
27
Apr

Beginner and Intermediate Nootropics

by adminadam in articles

Nootropics are “Safe” Smart Drugs, supplements which can help you think clearly and focus, remember things better, and boost your mood. These supplements — while admittedly less dramatic — are infinitely safer than adderall but with near-zero side-effects.

If you’re just entering into the field of Nootropics, or are considering taking something to boost your mood or cognition, please keep the following caveats in mind:

  • Don’t expect a miracle — this is rule number one. Many of these substances have subtle or gradually-building effects.
  • Don’t expect increased motivation — this should come primarily from inside yourself. I think visualization and meditation practice are much more powerful tools for increasing motivation and overall well-being than any of the nootropics listed below.
  • Don’t expect a dramatically different experience of reality — again subtle effects are common: Increases in visual information processing, listening comprehension, multitasking ability, reading speed, spatial awareness, feelings of calm, etc., may emerge.
  • Sleep, exercise, and diet are your primary Nootropics — don’t neglect these fundamentals.

Here is what I recommend for the curious, new Nootropics user…

The Racetams:

PIRACETAM — A water-soluble white powder which is thought to work by increasing acetylcholine uptake and cell-membrane fluidity in the brain. Dissolve 1 to 2 grams into a tall glass of fresh, clean water, stir once or twice, and imbibe.

Many users of Piracetam report noticeable boosts to their verbal fluency, short-term memory, reading comprehension or reading speed, and mental energy. It is also shown to be neuroprotective and can help alleviate the discomfort associated with altitude sickness. Maximum blood-plasma levels of piracetam are reached after one hour, but you may notice its effects within minutes. Up to 10-gram doses have been shown to be non-toxic, producing few side-effects, if any: perhaps a headache and, for some people, irritability.

My recommended doses range anywhere between 1 and 2 grams. (It’s very forgiving stuff.) You can take it two or three times a day as well. I usually recommend redosing every 6 hours or so. My recommended suppliers are Powder City ($12.50 per 100 grams) and New Star Nootropics ($17 per 100 grams). If you take 3 grams of it every day that should last you just over a month (33 days).

ANIRACETAM — A fat-soluble white powder this time, which is thought to work on acetylcholine uptake like piracetam, but also has mood-bossting effects due to its AMPA-kine-type qualities. It re-sensitizes your brain to to neurotransmitter glutamate, hypothetically leading to reduced excitoxicity and more balanced signaling in the brain. It is seen as an anxiolytic racetam, meaning it reduces anxiety, boosts your focus, and calms you.

To consume aniracetam, either mix the powder in with olive oil or some other kind of oil — or else put the powder straight into your mouth and gulp it down with a bunch of water. This is the quickest way because it’s not water-soluble. Keeping it under your tongue momentarily before washing it down is likely to accelerate bioabsoption and lead you to experience the boost in cognition quicker.

Aniracetam has a half-life in the body of 1 to 2 hours, versus Piracetam’s 7 to 8. Aniracetam is significantly more powerful, however, for promoting anxiolysis and short-term memory performance. The ideal starting dose, I feel, is around 800mg; although, I often take 1 or even 1.5 grams at a time. Some researchers may tell you otherwise, but it does not need to be consumed with a source of fat (despite that it is a fat-soluble supplement). Taking it 3 or 4 times a day may be best due to its short half-life. Recommended suppliers are: Powder City ($28 for 100 grams) or New Star Nootropics ($36 for 100 grams) — in either case roughly a 40-day supply.

OXIRACETAM — A water-soluble white powder like Piracetam. Recommended dosages for this one are 800mg to 1.2 grams. It is noted most often for its boosting of spatial awareness and logical thinking, moreso than other Racetam-type compounds. The half-life is 7 hours. Take it two or three times per day.

Oxiracetam is significantly more expensive than the others, however, some users prefer this over piracetam, reporting that it helps more with complex, information-dense tasks. Note: Mileage may vary. I bought 50 grams, a month’s supply, to try from New Star Nootropics for $31. It’s also available from Powder City at $25 for 50 grams.

Oxiracetam, Aniracetam, and Piracetam are my three recommendations for you if you’re just beginning to explore the field of Nootropics. If you notice their effects and feel neutral or even positive in terms of your mood after taking them then this is a good sign. If you feel significantly more anxious, then perhaps the Racetams aren’t for you. But don’t despair — there are many more safe and effective cognition-enhancing supplements under the sun! (See ‘Besides the Racetams’ below.)

Testing out the Racetams:

After taking one of these three entry-level Racetams for the first time, try the following:

  • Listen to a song whose words you don’t know by heart — Can you easily pick out the words?
  • Try skimming a news article to get the gist — Can you read it while skipping lines or sets of words? Can you read and comprehend it any faster than usual?
  • Try going outside and looking at the plants and trees and animals — Do you notice more details than you would normally?

If you don’t notice anything and still feel fine emotionally (i.e. not anxious), try a few more times later on (8 hours later, or the next day). Consider increasing the dosages by 50% or so for your next attempt if you feel fine but don’t notice anything yet. Aniracetam dosage should be increased perhaps by only 10% at a time in my experience; a little bit seems to go much further than with the others.

A little more scientifically…

Many researchers and students of nootropics test and train their cognitive abilities through tasks such as Dual N-Back (about: wikipedia). Try for yourself if you are interested in seeing what these tests are like: Lumosity, Brainscale, Brain N-Back (android app), Dual N-Back (iOS app). These can help you understand and hone your memory over time, regardless of whether you are taking any nootropics.

Besides the Racetams, what else is good for me as a beginner?

Other excellent nootropics include Choline Supplements to accompany the Racetams, L-theanine to accompany caffeine if you’re a coffee drinker, and the Amazing, Adaptogenic Herbs: Ashwagandha, Bacopa, and Rhodiola.

CHOLINE SUPPLEMENTS such as CDP-choline and Alpha-GPC help your brain to be able to produce more acetylcholine, an essential neurotransmitter. These are often most beneficial when taken with one of the Racetams like I’ve described above, although even these alone can boost verbal fluency and short-term memory. Take 200 to 300 mg of these substances two times a day for best results. Note that overdoing it can lead to some depressive symptoms potentially. Highly recommended if you have little choline in your diet — if you never eat eggs, for instance. Good to combine with Piracetam, Aniracetam, and/or Oxiracetam. The idea is that the Racetams rev up your engine, while Choline supplementation keeps the ‘acetylcholine gas tank’ full.

Fine to combine. In case you’re wondering… Yes, it is okay to consume different Racetams simultaneously if you wish to experiment further. Many researchers do. Each one is purported to act on subtly different mechanisms in the brain. I would still advise you to test them out individually first to get a feel for their different effects, however.

L-THEANINE is a compound in green tea (and other teas) which is relaxing and anxiety-reducing and helps to ameliorate the side-effects of caffeine, namely: anxiety and muscle-tension. I find it helps me remain calm and stay focused when I consume a lot of caffeine. It is recommended that you take two times more L-theanine than caffeine, though, in order to derive the greatest benefits from this powerful combination. One of the easiest ways to do this is with a supplement that contains both ingredients in this 2:1 ratio. I like Natural Stack’s Smart Caffeine. It has 200mg L-theanine and 100mg caffeine per capsule, which is perfect. You should notice greater focus and reduced jitteriness and muscle tension if you typically consume caffeine. Smart Caffeine is around $20 for 60 capsules, but most likely is the highest quality supplement of its kind. Powder City also sells capsules with these same ingredients and proportions. They sell 90 capsules for just $10. I’ve used the Powder City capsules too and they work just as well.

ASHWAGANDHA is an anxiolytic adaptogen (an anxiety and stress-reducing herb) much lauded in Ayurveda. It is also said to increase virility and male fertility, and boost the immune system. It seems to reduce my anxiety and encourage more pro-social tendencies in me, like sustained eye-contact. I use Nutrigold (Ashwagandha Gold). It is $18 for 90 capsules, organic, with a high-potency standardized extract, KSM-66. Very cost effective if you ever get nervous or anxious in social situations. Take two per day.

BACOPA MONNIERI is another ayurvedic herb shown to boost memory and help you fight anxiety. It is one of the most studied herbal nootropics, and one that is a key part of my stack. NOTE: Memory and cognition enhancement aspects of this supplement may take up to 8 weeks of daily use to kick in. Anxiolytic (calming) effects should be apparent early on (similar, but likely less pronounced in this regard, to Ashwagandha). I use the Bacopa with the standardized BaCognize extract from Swanson Superior Herbs. This costs $12 for 90 capsules. Take two per day.

Bacopa and Caffeine with L-theanine are probably the safest bets overall. Very cost effective, too. They’re well-supported in research for memory enhancement (Bacopa) and sustained focus (Caffeine/L-theanine) in non-elderly (and also elderly) populations. Click on the links at the beginning of each respective paragraph to read more research on them from Examine.com.

RHODIOLA ROSEA is a Traditional Chinese Medicine and Scandinavian adaptogenic herb used to fight fatigue and exhaustion. It is a potential neuroprotective agent, and has been shown to boost longevity in animal studies. It is serotonergic, meaning it acts upon serotonin receptors in the brain, and it is reported to enhance general subjective well-being and cognition through its anti-depression and anti-fatigue-type effects. I found this helpful when I hadn’t slept enough; it gave me a boost of energy and also seemed to help me keep my stress levels low. I recommend NOW Foods Rhodiola Rosea. 60 capsules for about $8.50. If you find you like other brands more, just make sure they contain the active compounds at these percentages: 3% Rosavins and 1% Salidroside. This ensures potency. With all Rhodiola supplements, take just ONE dose in the morning. BONUS: Rhodiola may help reduce the symptoms of cessation of smoking. Additionally, some users report it helps them to cycle or go off of caffeine.

Intermediate Nootropics:

After exploring L-theanine, the Racetams, choline, and the adaptogenic herbs, I might consider testing out some of the following newer, and more powerful Racetams:

NOOPEPT is a highly-potent piracetam analogue. It is said to increase Brain Derived Neurotrophic Factor and Nerve Growth Factor. This means increasing neuro-plasticity, potentially. It is often recommended that you take it for a period of time and then cycle off of it, for instance, two months on, and then one week off. A friend of mine said he noticed some personality changes in himself with noopept: He became much more serious and focused, yet less fun-loving in his own estimation. I feel that noopept is stimulating and helps me to focus on whatever I’m doing. I believe it is helping me retain more information in my short-term memory. It is also said to be neuroprotective and immuno-restorative. Doses of 10mg to 30mg are recommended, twice daily. I got mine from Powder City. If you take 30mg a day, a 1 gram container will last you for a month — and it costs only $5! I believe this one stacks particularly well with aniracetam — where noopept stimulates me and promotes quick and logical thinking, and aniracetam keeps me calm and encourages creativity.

COLURACETAM is a newer piracetam-analogue with the potential for longer-lasting effects on memory. Even tinier doses are used than noopept this time: 3 to 10 mg is suggested for coluracetam for each dose. Research indicates it promotes High Affinity Acetylcholine Uptake, indicating it more directly affects and increases the activity of cholinergic neurons. There is scant evidence of nootropic benefit to healthy populations at this time, but it has been shown to preserve choline uptake into neurons when they are otherwise impaired. A number of intrepid and daring nootropic adventurers who’ve tried it self-reported and indicated they felt similar cognition-boosting effects as with other racetams. Some noted a mood-boost and increased motivation as well. I tried a batch of Powder City’s coluracetam a while back and felt similarly about it, but knowing of its unproven track record and uncertain safety profile, I’ve set this one aside until future studies can substantiate the hype and settle some of the questions surrounding it.

PRAMIRACETAM is a another piracetam analogue, this time with minor evidence of memory-enhancing and neuroprotective effects. It may promote High Affinity Acetylcholine Uptake, but no clinical trials have been conducted on human subjects at the time of this writing. As the editors at Examine.com note, it has structural similarities with both piracetam and choline, and so may break off into these two compounds or similar compounds after crossing the blood-brain barrier. Some users report that this Racetam is amongst the best for sustained focus and concentration. Typical doses are 300 to 600 mg twice a day. WARNING: Do not consume the powder form directly — it burns your mouth and tongue terribly. I recommend you mix and dissolve it into olive oil or another vegetable oil for a couple of minutes, and then maybe drink it down with milk or some other fatty beverage — yogurt could work too, I suppose. (The taste is absolutely wretched!) I got some from Powder City to try. It was $40 for 25 grams, a 20-day supply.

Further Resources:

  • Want more suggestions? If you’ve tried all of these and are looking for other suggestions of things to experiment with, hit me up at 84adam [at] thrivenotes [dot] com.
  • Wondering about certain combinations? See Reddit’s StackAdvice subreddit if you’re planning a combination of various Nootropics to take and want feedback from the community there.
  • Tell me more about it all! Check out Reddit’s /r/Nootropics’ A Beginner’s Guide to Nootropics for reliable suppliers, safety information, and more. Highly recommended reading!
  • Got feedback? If you’ve got feedback or an experience report for one of the supplements I’ve listed then please comment below!

Happy Experimenting! : )

23
Jan

Nootropics, i.e. “Safe” Smart Drugs

by adminadam in articles

Nootropics (say “New-Trow-Pics”) are drugs that provide some form of cognitive enhancement and yet are shown to be, if not neuroprotective, at least non-toxic and safe to use. These drugs work by A) making certain neurochemicals more available in the brain, B) by increasing the brain’s oxygen supply, or C) by stimulating nerve growth.

I first became interested in smart drugs (and subsequently nootropics) when a friend in college told me she took Adderall occasionally to boost her productivity (a non-ADHD-related use). She told me she could easily stay awake for 24+ hours and feel alert, clean her dorm room from top to bottom, write a paper or two, and so on. It should be noted, however, that in speaking of nootropics, we should not include Adderall, because it has numerous potential side-effects that may stem from non-prescription use: addiction, heart problems, depression, nausea, etc. (source: webmd)

A powerful and commonly-used smart drug these days is Modafinil. It is a “wakefulness promoting agent”, meaning it keeps you awake and alert, and is prescribed generally for narcolepsy and other sleeping disorders, in addition to ADD. It is has been used by soldiers on long missions and even by Canadian astronauts serving on the International Space Station. As noted by Andrew McMillan, a Journalist for Rolling Stones (Australia) who experimented with the drug, while it may not be addictive, after three consecutive days on the drug — staying up for 79 out 90 hours:

I felt as though I’m not making sense, and that those around me are acutely aware of this. I feel in control, but my mind is racing faster than my mouth can keep up. … Around 2am, I note that I’ve got an impending feeling of doom going on. Like I’m riding this too far, and it’s about to start doing some serious damage.

After sleeping a full-night’s sleep and erasing some of his sleep debt, he remarks further:

I reflect on how my views toward modafinil have veered between utter devotion to, now, in the cold light of day, a realisation that it’s probably not a good idea to be taking that shit on consecutive days.

Despite the illegality of off-label use in most places, one study in the journal Nature estimated that up to 25% of students at some campuses had taken neuroenhancing drugs like Modafinil in the past year. Many students have reported that it helps them to stay alert and perform — both mentally and physically — and that when final exams approach, the temptation to ‘take something’ can be overwhelming.

It seems that, as it may not be a safe long-term solution to the desire to enhance cognitive function, perhaps it is best to look at other (and more legal) options for those that would like to improve their memory, accelerate their learning, or simply be able to work longer each day. These nootropics should all be milder, safer, and more effective over the long-term, according to my research:

      1. PIRACETAM + CDP-CHOLINE — Piracetam is a safe and effective cognitive enhancer that is thought to restore membrane fluidity of compromised neuronal cells (helping with neuro- transmission, protection, and plasticity). It was first used in the 1960’s to combat motion sickness. Its companion (I’ve listed them together intentionally) is CDP-Choline, which is a choline supplement, so it increases the amount of choline available to the brain. (Choline, or Acetylcholine, more properly, is one of the primary neurotransmitters in your brain; without sufficient choline, your brain can’t function well.) [Read more about both of these substances, including how they work together, at SmarterNootropics.com]
      2. ANIRACETAM + CDP-CHOLINE — Similar to Piracetam, being in the “racetam” family, but this is a fat-soluble version, so it won’t dissolve in water. Aniracetam is purported to have an anxiolytic (read: anxiety-reducing) effect as well as the memory and word recall-boosting effects like that of piracetam. [See more here: smarternootropics.com/table-of-contents/aniracetam/.]
      3. PYRITINOL — Pyritinol is a modified form of vitamin-B6. It is two B6 molecules combined together so that — when broken down by your body — they can easily cross the blood/brain barrier to help with neurotransmitter synthesis. It has been shown to improve reaction time in individuals in time-based tests and is used to help treat dementia in some places in Europe. It has been in use as a nootropic since the 1990’s. (Interesting to note that it is also known as an effective “hangover cure”.)
      4. MAGNESIUM L-THREONATE — While magnesium is apparently one of the most deficient minerals in the American diet, eating foods high in the mineral and taking supplements is unlikely to positively impact your brain for the reason that these forms of magnesium cannot easily pass through the blood/brain barrier. With this challenge and the knowledge that in-brain magnesium is vital to synapse density, recognition memory, and spatial working memory, MIT sought to find a form that can easily get where it needs to go, hence: Magnesium L-Threonate, or MgT. In lab animals given it it led to 18% improvements in short-term memory and 100% improvements in long-term memory. It is currently being tested in human trials.

There we have it — four nootropics for the uninitiated to look into! Please let me know in the comments if you have insights into (or experience related to) these or other cognitive enhancers.